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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK2
All Species:
22.12
Human Site:
S356
Identified Species:
34.76
UniProt:
P51955
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51955
NP_002488.1
445
51763
S356
E
N
L
L
K
N
Y
S
L
L
K
E
R
K
F
Chimpanzee
Pan troglodytes
XP_514178
522
59597
S433
E
N
L
L
K
N
Y
S
L
L
K
E
R
K
F
Rhesus Macaque
Macaca mulatta
XP_001108740
445
51674
S356
E
N
L
L
K
N
Y
S
L
L
K
E
Q
K
F
Dog
Lupus familis
XP_537144
668
75595
S579
E
N
L
L
K
N
Y
S
L
L
K
E
Q
K
F
Cat
Felis silvestris
Mouse
Mus musculus
O35942
443
51289
Y355
A
E
S
L
M
K
N
Y
S
L
L
K
E
H
R
Rat
Rattus norvegicus
XP_001055166
443
51340
Y355
A
E
S
L
L
K
N
Y
S
L
L
K
E
H
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509538
499
57433
N410
E
N
L
M
R
N
Y
N
L
L
K
E
Q
R
I
Chicken
Gallus gallus
NP_001026221
444
51581
S355
E
K
L
M
R
N
Y
S
L
Y
K
Q
Q
R
T
Frog
Xenopus laevis
NP_001079490
442
52004
E348
E
D
K
I
A
R
A
E
S
L
V
K
N
F
N
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
S497
H
N
C
P
Q
Q
V
S
L
P
A
D
F
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572415
735
82962
A425
E
A
P
S
S
P
R
A
L
T
Q
N
I
F
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786794
453
51921
E323
T
Q
M
L
N
D
R
E
K
E
L
D
L
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
A510
K
A
V
Y
E
E
D
A
Y
L
E
D
R
S
E
Baker's Yeast
Sacchar. cerevisiae
P22209
435
51185
A318
Y
Y
S
R
G
L
N
A
I
I
H
S
M
I
D
Red Bread Mold
Neurospora crassa
P48479
858
94329
S464
Y
S
S
A
P
A
E
S
V
L
G
T
P
M
D
Conservation
Percent
Protein Identity:
100
85
98.4
62.5
N.A.
87.6
89.4
N.A.
69.7
77
73.9
25.8
N.A.
30.2
N.A.
N.A.
54.3
Protein Similarity:
100
85
99.3
65.4
N.A.
94.1
95
N.A.
80.9
88.7
86.7
39
N.A.
44.3
N.A.
N.A.
72.1
P-Site Identity:
100
100
93.3
93.3
N.A.
13.3
13.3
N.A.
60
46.6
13.3
20
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
20
20
N.A.
93.3
80
33.3
40
N.A.
26.6
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
22.7
24.3
Protein Similarity:
N.A.
N.A.
N.A.
44.8
43.8
36.1
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
20
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
14
0
7
7
7
7
20
0
0
7
0
0
0
7
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
7
7
0
0
0
0
20
0
0
20
% D
% Glu:
54
14
0
0
7
7
7
14
0
7
7
34
14
7
14
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
14
27
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
7
0
0
14
0
% H
% Ile:
0
0
0
7
0
0
0
0
7
7
0
0
7
7
7
% I
% Lys:
7
7
7
0
27
14
0
0
7
0
40
20
0
27
0
% K
% Leu:
0
0
40
47
7
7
0
0
54
67
20
0
7
0
0
% L
% Met:
0
0
7
14
7
0
0
0
0
0
0
0
7
7
0
% M
% Asn:
0
40
0
0
7
40
20
7
0
0
0
7
7
0
7
% N
% Pro:
0
0
7
7
7
7
0
0
0
7
0
0
7
0
0
% P
% Gln:
0
7
0
0
7
7
0
0
0
0
7
7
27
0
0
% Q
% Arg:
0
0
0
7
14
7
14
0
0
0
0
0
20
20
14
% R
% Ser:
0
7
27
7
7
0
0
47
20
0
0
7
0
7
0
% S
% Thr:
7
0
0
0
0
0
0
0
0
7
0
7
0
0
7
% T
% Val:
0
0
7
0
0
0
7
0
7
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
14
7
0
7
0
0
40
14
7
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _